2nd International Probiotics, Nutrition & Microbiome Conference
October 10-11, 2018 Amsterdam, Netherlands
Effect of Probiotics and Prebiotics on Gut Integrity in Critically Ill Patients
Prince Sultan Military Medical City, Saudi Arabia
Gut failure is common in ICU patients which characterized by lack of bowel sounds, regurgitation, vomiting, high gastric residual volumes (>500 mL/day), diarrhea, constipation, abdominal distension or GI bleeding. During critical illness, several factors might affect gut microflora that involve changes in stress hormones, gut ischemia, use of antibiotics and immune suppression, gut micrbiota, lack of nutrients and enteral feeding failure. Unfortunately, clinical evaluation of the gut function is difficult therefore gut dysfunction usually goes unrecognized related to poor clinical outcomes and high morbidity and mortality rate. Diet has the strongest effects on gut microbial colonization that could modify the profile of dominant species in human gut and offer different consequences of health. Recent data suggested to preserve or reestablish a healthy gut microbiota during and after critical diseases through targeted interventions such as probiotics, prebiotics, fecal microbial transplants (FMT), and synthetic ‘stool pills’. This review developed to evaluate the efficacy of probiotic/prebiotics in critical ill patients. Probiotics offers many benefits to the host including effective in the treatment or prevention of acute gastroenteritis, GI dysfunctions, antibiotic associated diarrhea (AAD), certain pediatric allergic disorders, necrotizing enterocolitis and inflammatory bowel disease (IBD). Briefly, probiotics use in the ICU remains widespread and no definitive recommendation for the routinely probiotics use in critical ill patients. Further studies are required to define the dose, types and safety of pro- and prebiotics in critically illness.
Keywords: Probiotics, prebiotics, critically ill patients, Antibiotic associated diarrhea, Clostridium difficile-associated diarrhea, Ventilator-associated pneumonia.
Daniyah Abdullah Alkhawtani is a clinical dietitian at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. She obtained Bachelor of clinical nutrition from King Saud University, College of Applied Medical Sciences, Riyadh in 2011. She began her Master of clinical nutrition in 2013. Furthermore, she obtained Diploma in Sport and Exercise Nutrition. She Participated as a speaker in the advance course for residentʼs level 3(2015), 5th Clinical and Community Nutrition Update in Riyadh, Saudi Arabia (2016), 8th International Conference of Clinical Nutrition in Dubai (2016), 6th International Conference and Exhibition on Probiotics, Functional and Baby foods. London, UK, October 2017 and in 1st Annual Scientific Meeting of Saudi Arabia Parentral and Enteral Nutrition (SAPEN) Madareem Crown Hotel. Riyadh, Saudi Arabia April 2018.