2nd International Probiotics, Nutrition & Microbiome Conference
October 10-11, 2018 Amsterdam, Netherlands
Supplementation with Bacillus clausii Doesnot Improve the Therapeutic Outcomes in Atopic Eczema – Results of an Observer Blinded Parallel Group Randomized Controlled Study
1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical, Education and Research, India
2Department of Endocrinology (Immunology Division), Postgraduate Institute of Medical Education and Research, India
Background: Atopic dermatitis (or atopic eczema or AD) is an itchy, chronic, or chronically relapsing, inflammatory skin condition
Objective: To study the effectiveness of probiotics supplementation (Bacillus clausii) in achieving clinical remission, preventing relapse and its effect on immunological profile in children with AD.
Methods: In this randomized controlled study where one hundred and fourteen patients of atopic dermatitis aged 6 months to 12 years were recruited and randomly allocated into two groups comprising 57 each with Group A receiving conventional treatment with probiotics and group B receiving only conventional treatment. Baseline SCORAD and follow up SCORAD at 4, 8, 12, 16, 20 and 24 weeks were measured. IL-17A levels were measured at baseline and 12 weeks.
Results: There was no any significant difference in the main clinical outcome (SCORAD) by administration of Bacillus clausii in children with AD between group A receiving probiotics along with conventional treatment and group B receiving only conventional treatment at 12 weeks (p=0.21), and at 24 weeks (p=0.26). IL-17A levels were not significantly different between two groups after the probiotics supplementation at 12 weeks (p=0.7) .The mean IL-17A level decreased from baseline in Group A with probiotic supplementation whereas the mean IL-17A concentration increased in group B at 12 weeks though the mean difference between two group was not significant. There was no statistically significant correlation between IL-17A levels and AD severity.
Conclusion: Supplementation with the probiotic Bacillus clause to conventional treatment does not offer any additional benefit in inducing remission or prevention relapse in AD.
Biography:
Dr. Richa Sharma is from Nepal & currently practicing as a consultant dermatologist in private clinic. She did her post graduation from a renowned center i.e Postgraduate Institute of Medical Education and Research (PGIMER) which is a course of 3 years duration during which she worked in the department of Dermatology, venereology and leprology. She did her thesis on this particular topic on probiotics in allergic disease.
