Madridge Journal of Dermatology & Research

ISSN: 2639-0353

International Dermatology, Cosmetology and Skin Care Conference

January 19, 2021, Virtual Conference
Scientific Session Abstracts

Enviroageing: The Impact of Urban Pollution, Infrared and Visible Light on Human Skin

Terri Vinson

Synergie Skin, Australia

The impact of environmental pollution and solar radiation (UV, IR and HEV) are the major contributors to cellular damage, free radical formation and enviroageing.

Until recently, the aesthetics industry has been solely focused on the harmful effects of UV wavelengths of radiation only. However, we are now looking beyond the UV spectrum at the negative impact of infrared light and HEV light (in particular blue light) and the potentially damaging interaction with epidermal and dermal cells.

Moreover, the impact of urban pollution is now recognized as a significant factor contributing to cellular inflammation and extrinsic ageing.

Science is now able to look beyond UV into enviroageing and discover novel ingredients to combat environmentally based cellular damage and inflammation. This presentation investigates the impact of urban pollution and radiation beyond UV on the viability and function of human skin cells:

1. Dermal impact of environmental pollution

2. Discussion of Infrared (IR) light and effect on human cells

3. Overview of UVA and UVB damage and impact on human skin cells

4. Impact of HEV (High energy visible) blue light on dermal viability

5. Protective cosmeceutical ingredients to mitigate enviroageing

Terri holds a Bachelor of Science, a post-graduate Diploma of Formulating Chemistry and a Diploma of Education. She is a published author, leading female formulator and an expert in the field of cosmetic science and skincare. She is the founder of Australian brand Synergie Skin, Terri Vinson is dedicated to creating highly active cosmeceutical and intelligent mineral makeup. In accordance with her trademarked ‘Clean Science’ philosophy, she is dedicated to formulating safe and ethical products that protect, change and nurture skin and promotes long-term dermal health.

In Vitro and In Vivo Cutaneous Wound Healing Activity of Hydroethanolic Extract from Leaves of Aloe buettneri (Liliaceae)

Kossi Metowogo

University of Lome, Togo, West Africa

Aloe buettneri is used in Togolese traditional medicine to treat several skin diseases including wounds which is a public health problem. This study aimed to assess the healing activity of hydroalcoholic extract from Aloe buettnerion skin wounds. Tissue damage model is used for in vitro activityusing bronchial epithelial cell16HBE grown. Also, Excision wound model in balb/c mice was evaluated. The results showed extract of A. buettneri increases the tissue repair of bronchial epithelial cell 16HBE grown in their respective culture medium with 0.3% SVF. Then eighteen hours after induising lesion, the percentage of healing in 16HBE cells in the medium supplemented with 50 µg/ml extract is almost 100% whereas in the control, it is approximately 65%. Carbopol gel containing 2,5% extract stimulates skin woundhealing in mice. Wound healing is assessed by the reduction of the wound surface area. The difference between the healed areas observed in controls and treated mice is significant (P < 0,05). These results prove the use of Aloe buettneri among traditional recipes for treating wounds in the pharmacopoeia but further studies remain important to produce traditionally improved drugs.

Keywords: Wound-healing, Cell proliferation,16HBE cells, balb/c mice

Metowogo Kossi is currently working as Lecture and Researcher at University of Lome, Faculte des Sciences Laboratoire de Physiologie- Pharmacologie. He has completed his Ph.D. in Physiology, Pharmacology from Universite de Lome, Togo. His main area of interest focuses on Physiology and Pharmacology. His area of expertise includes Natural Substance, Pharmacology, Toxicology, Gastric Ulcers, Asthma, Wound Healing and Phytochemical Screening. He has 7 publications in journals as author/co-author.

The Treatment of Chloasma in Traditional Chinese Medicine

Huang Wei Ling

Medical Acupuncture and Pain Management Clinic, Brazil

Introduction: Chloasma is a condition in which dark patches appear on the skin, most commonly on the cheeks, bridge of the nose, forehead, upper lip and chin– areas of the face that receive the most sun exposure. In Traditional Chinese Medicine (TCM) the causes of the disease could be Liver-Qi stagnation, Spleen-deficiency, Kidney-Yin-deficiency and Kidney-Yang-insufficiency.

Purpose: The purpose of this study is to demonstrate that to successfully treat Chloasma you need to look for the roots of the problems, not only the symptom.

Methods: Over two case reports, the first being a 42-year-old woman who sought Acupuncture treatment for chronic headache and had the doctor notice the skin stains disseminated on her face, especially in the cheeks area. The second case, a 48-year-old man with constant knee pain was on Acupuncture treatment and at his physical examination, there was found several dark patches on his face. Both patients were diagnosed with energy imbalance (Yin, Yang, Qi and Blood) and were treated with Acupuncture sessions associated with Chinese dietary counseling.

Results: Both patients had a significant improvement of the Chloasma patches, even thought that wasn’t the main cause of complaint. This overall recovery was achieved with the treatment of the patient in a holistic aspect, because when the energy imbalance that is causing problems is cared for, all the physical and / or emotional symptoms of one or several medical specialties improve at the same time.

Conclusion: The treatment of Chloasma in TCM has a different point of view from Western medicine, by treating deeply the root cause of the problem in its energy level. Each patient has their own imbalance and the treatment must be individualized to have successful results.

Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998. Since 1997, she has been presenting her work worldwide, working with the approach and treatment of all diseases of all systems of the human body in a holistic way, with treatment guided through the teachings of Traditional Chinese Medicine and Hippocrates.

Targeting the Dermal Matrix for Skin Anti-aging

Siming Chen and Lisa Di Natale

Global Innovation Center, Avon, USA

Cutaneous aging is a complex process involving a series of cellular and extracellular matrix events. The dermal matrix of the skin plays a pivotal role during this process. Studies by us and other investigators have consistently found that dermal matrix progressively degrades throughout a person’s life. The manifestation of this progressive reduction of dermal matrix is the loss of skin elasticity, which may in turn lead to gradual appearing and/or deepening of facial lines, wrinkles and increased sagging.

It was postulated that enhancing dermal matrix protein production, assembly and stabilization can contribute to improve facial volume and firmness over time, thereby slowing down the appearance of skin aging. To investigate this possibility, a screen of synthetic substances and medicinal herbs was conducted to identify cosmetically acceptable substances that can influence the production and stabilization of dermal matrices. We identified a substance that showed strong stimulatory effect on dermal matrix components, such as collagen, elastin and hyaluronic acid in an in vitro model. Formulation that contains this substance has shown a stronger collagen-boosting effect than the formulation that contains Hydroxypropyl tetrahydropyrantriol in the 48-hour treatments on skin reconstructive tissues. A double blind placebo controlled split-faceclinical efficacy study was conducted using bio-instrumentation, After 4-weeks of use, results showed significant treatment improvement over placebo in firming and smoothing of skin. Subsequent clinical trials were performed where significance was observed on various skin conditions. In this presentation, our findings from both in vitro and in vivo studies will be shown and discussed.

Siming Chen is a Research Fellow of Avon Products Inc., where her primary research focus is on anti-aging skin biology and pigmentation. Prior to joining Avon, She was a Research Associate in Weill Medical College of Cornell University, investigating molecular mechanisms of retinoid on stem cell growth and differentiation.
Lisa Di Natale, M.S., joined Avon in 2001 and is currently Senior Manager Clinical Efficacy. Lisa’s long history within clinical testing brings invaluable knowledge determining product performance. Currently, she leads efforts on study design for unique Clinical assays and claim substantiation for Avon products globally across categories with focus on skincare, color and personal-care.