Virginia Tech, USA
The age of highly antibiotic-resistant strains of bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and tuberculosis (TB) has been identified as a world-health crisis given the number of cases and deaths from these two pathogens alone. The Infectious Disease Society of America made a statement in 2010 that at least 10 new antibiotics would need to be developed by 2020 (The “10 x ‘20 Initiative) and unfortunately, that did not happen. As serious as the problem of antibiotic resistance is, it has recently paled in comparison to the world health crisis of the pandemic of COVID-19. In the COVID crisis, the lack of an effective vaccine and of effective anti-virals has resulted in a massive loss of life around the globe.
This talk will present findings on how organometallic complexes with appropriate ligands, such as amino-acids, can combat resistant bacteria while still being safe for mammalian cells and in our latest results, some compounds may show anti-viral activity. A class of compounds effective against tuberculosis and a second class effective against MRSA will be described. Preliminary results on a newer class of organometallic compounds with anti-viral activity will be touched on only briefly since the results are very preliminary.
Joseph S. Merola received his Ph.D. in 1978 with Dietmar Seyferth at MIT. He joined the Corporate Research Laboratories of Exxon Research & Engineering Company in New Jersey. In 1987, he moved to the Department of Chemistry at Virginia Tech where he has remained since. He carries out work in the areas of transition metal organometallic complexes, primarily of rhodium and iridium. This work began as an investigation into their catalytic activity and morphed into examining their biological activity. Professor Merola is a Fellow of the American Chemical Society and a Fellow of the American Association for the Advancement of Science.
Rutgers University, USA
Ions and Water Molecules have been long known to play crucial roles in governing biomolecular stability and function. Elucidating how ions and water molecules distribute themselves around the solutes should provide valuable insights in the mechanism of how those molecules function and also provide experimental tests for theoretical predictions. I will discuss the 3D-RISM integral equation approach, emphasizing tests that involve comparisons to X-ray scattering results both in solution and in crystals and to ion-counting experiments for nucleic acids.
David A. Case has worked in the area of biochemical computer simulations for more than 40 years. He received a Ph.D. from Harvard University and has worked at the University of California, Davis, The Scripps Research Institute and Rutgers University. Research interests include compuatational aspects of biomolecular NMR and crystallography and the development of molecular dynamics-based simulation methods. He leads the team that develops the Amber suite of biomolecular simulation programs.
Drexel University, USA
I will present a summary of some optoelectronic applications of red and black phosphorus nanomaterials. The synthesis, characterization, stability improvement of the materials will also be discussed.
Hai-Feng (Frank) Ji is currently a professor of Department of Chemistry, Drexel University. His research interests focus on MEMS devices, nanomaterials for energy and environmental applications, drug discovery, nanopillars and phosphene for energy applications and surface chemistry. He is currently a co-author of 185 peerviewed journal articles and book chapters. He has an H-index of 35. He is an editorial board member of several chemistry journals.