International Conference on Alzheimerʼs Disease & Associated Disorders
May 7-9, 2018 Rome, Italy
Effect of Lycoris chejuensis and its Active Components on Experimental Models of Alzheimerʼs Disease
1Natural Products Research Center, Korea Institute of Science and Technology, Republic of Korea
2Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Republic of Korea
3Department of Life and Nanopharmaceutical Science & Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, Republic of Korea
4Department of Biological Chemistry, University of Science & Technology (UST), Republic of Korea
We found that an extract of Lycoris chejuensis, and its three isolated active components, narciclasine, 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine, each significantly reduced the formation of amyloid-β peptides in HeLa cells transfected with an amyloid precursor protein carrying the Swedish mutation up to 45±3.6%. The extract down-regulated amyloid precursor protein, especially the mature form by up to 88%, and reduced the ability of secretases to generate toxic amyloid-β. Double-transgenic mice treated with the extract for 4 months also showed significantly reduced levels of amyloid-β and plaques while exhibiting improved memory functions in the Morris water maze and novel object recognition tests. In conclusion, the extract and isolated active components of L. chejuensis decreased the production of amyloid-β by attenuating amyloid precursor protein levels. Furthermore, the extract improved the disrupted memory functions in animals while inhibiting amyloid plaque formation. Thus, this extract, as well as its active components, could prove beneficial in the treatment of Alzheimerʼs disease.
Keywords: Lycoris chejuensis, Alzheimerʼs disease, Amyloid-beta, Amyloid-beta precursor protein, Narciclasine
Hyun Ok Yang has complete her PhD on pharmacognogy at Seoul National University in 1993. After Post-doctoral study at University of Iowa, USA, she is now a principal research scientist at Natural Products Research Center in Korea Institute of Science and Technology (KIST) & a professor of UST, KIST School, Republic of Korea.