From 1992 to 1995 he worked as visiting fellow at the Cell Biology and Metabolism Branch, National Institutes of Health, Bethesda, USA, under the supervision of Dr Richard Klausner and he studied the mechanisms involved in intracellular protein trafficking regulation, focusing on the role of small GTP-binding proteins and coat proteins in vesicle formation.

In 1995 joined the group of Prof Alberto Albertini and Prof Cristina Alberini at the Univerisity of Brescia first as a post-doc with a fellowship from The Fondazione per le Biotecnologie (Turin, Italy) and then as an assistant professor and started to work on the biological functions of proteins involved in the pathogenesis of Alzheimer's disease and to investigate genetic aspect of neurodegenerative disorders. He focused his research on the biological regulation and function of the Amyloid Precursor Protein metabolism. He also extensively applied the DHPLC technology for the search of mutation affective the individual risk to develop Alzheimer’s and Parkinson’s disease.