Madridge
We publish journals with a view to serve various purposes which include but not limited to just peer review, broad distribution, branding and authority, portability and creation of the archive of a body of literature....
We publish journals with a view to serve various purposes which include but not limited to just peer review, broad distribution, branding and authority, portability and creation of the archive of a body of literature....
Editor Name: Burton M.Altura
Designation: Professor
University: Suny Downstate Medical Center
Country: USA
Biography: Burton M. Altura is currently working as a Professor of Physiology, Pharmacology & Medicine State University of New York Downstate Medical Center. Burton studies address the two most important issues in vascular biology today: stroke mechanisms; and irreversible cellular destruction in the cardiovascular system caused by alcohol and substance abuse. These studies have already led to the prevention of atherosclerotic lesions, hypertension and stroke-like events in experimental animal models. Additional experimental studies, using manipulations in divalent cation metabolism, have been very effective in the prevention and amelioration of alcohol-, phencyclidine-, cocaine-, and other substance abuse-induced strokes.
Editor Name: Burton M. Altura
Designation: Professor
University: State University of New York Downstate Medical Center College
Country: USA
Biography: Burton M.
Altura is currently working as a Professor of Physiology, Pharmacology &
Medicine State University of New York Downstate Medical Center. His studies
address the two most important issues in vascular biology today: stroke
mechanisms; and irreversible cellular destruction in the cardiovascular
system caused by alcohol and substance abuse. These studies have
already led to the prevention of atherosclerotic lesions, hypertension and stroke-like events in experimental animal models.
Additional experimental studies, using manipulations in divalent cation
metabolism, have been very effective in the prevention and amelioration of
alcohol-, phencyclidine-, cocaine-, and other substance abuse-induced strokes.
Editor Name: Burton M. Altura
Designation: Professor
University: State University of New York Downstate Medical Center College
Country: USA
Biography: Burton M. Altura is currently working as a Professor of Physiology, Pharmacology & Medicine State University of New York Downstate Medical Center. His studies address the two most important issues in vascular biology today: stroke mechanisms; and irreversible cellular destruction in the cardiovascular system caused by alcohol and substance abuse. These studies have already led to the prevention of atherosclerotic lesions, hypertension and stroke-like events in experimental animal models. Additional experimental studies, using manipulations in divalent cation metabolism, have been very effective in the prevention and amelioration of alcohol-, phencyclidine-, cocaine-, and other substance abuse-induced strokes.
Editor Name: Burton M Altura
Designation: Professor
University: SUNY Downstate Medical Center
Country: USA
Biography: Our laboratory is addressing two of the most important issues in vascular biology today: stroke mechanisms; and irreversible cellular destruction in the cardiovascular system caused by alcohol and substance abuse. These studies have already led to the prevention of atherosclerotic lesions, hypertension and stroke-like events in experimental animal models. Additional experimental studies, using manipulations in divalent cation metabolism, have been very effective in the prevention and amelioration of alcohol-, phencyclidine-, cocaine-, and other substance abuse-induced strokes.We are using intact animals, isolated organs, tissues and cells in culture to understand how divalent cations (Mg2+ and Ca2+), sphingolipids, lipid messengers, protein kinase C and nuclear transcription factors control normal fuctions of vascular smooth muscle cells, cardiac myocytes and several types of neuronal cells. In order to accomplish these goals, we employ various state-of-the-art techniques: NMR spectroscopy; in-vivo high-resolution TV microscopy; digital image microscopy; confocal laser scanning microscopy; culture of primary cells; Mg2+ ion-selective electrodes; mono- and polyclonal antibodies; antisense oligonucleotides; and lipid chemistry. Use of the various models and techniques has led us to hypothesize that magnesium ions can regulate voltage-, receptor-, and leak-operated membrane channels in a number of cell types and that various cellular signaling pathways, particularly isoforms of PKC and sphingolipids are turned on or off by the actions and concentrations of Mg2+ at multiple cellular sites.Research Interest: Physiology, Vagal Maneuvers, Pharmacology, Medicine
Editor Name: Burton M Altura
Designation: Professor
University: SUNY Downstate Medical Center
Country: USA
Editor Name: Burton M Altura
Designation:
University: State University of New York
Country: United States
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