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					<li><a href="#intro">Introduction</a></li>
					<li><a href="#diagnosis">Diagnosis</a></li>
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                    <p class="art-type" id="articleinfo">Mini-Review</p>
		    <p class="art-title">Dyslipidemia, Diabetes, and the Heart</p>
		    <p class="art-author"><?php $authors="Helmut Schatz<sup>*</sup>"; echo (stristr($authors,$coauthor))?str_replace($coauthor,"<a href='".$extpath."authors/".$courl."' target='_blank'>".$coauthor."</a>",$authors):$authors; ?></p>
<p class="art-affl">Ruhr-University, Bochum, Germany</p>
		    <p class="art-aff"><b>*Corresponding author: <?php $corresponding_author="Helmut Schatz"; echo ($coauthor!="" && $coauthor==$corresponding_author)?"<a href='".$extpath."authors/".$courl."' target='_blank'>".$coauthor."</a>":$corresponding_author;?></b>,
Ruhr-University,
Bochum,
Germany,
E-mail: <a href="mailto:helmut.schatz@ruhr-uni-bochum.de">helmut.schatz@ruhr-uni-bochum.de</a></p>
<p class="art-aff"><b>Received:</b>  September 27, 2016
<b>Accepted:</b>   November 2, 2016
<b>Published:</b> November 7, 2016</p>
<p class="art-aff"><b>Citation:</b>  Schatz H. Dyslipidemia, Diabetes,
and the Heart. <i>Madridge J Diabetes</i>. 2016; 1(1): 29-30.doi: <a href="https://doi.org/10.18689/mjd-1000105">10.18689/mjd-1000105</a></p>
 
<p class="art-aff"><b>Copyright:</b> &copy;   2016 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
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<p class="art-subhead" id="intro">Introduction</p>
<p class="art-para">During the European Congress of Cardiology in Rome, August 2016, the Joint
Guidelines of this Association together with the European Atherosclerosis Society about
the <b>"Management of Dyslipidemias"</b> has been published. In this mini-review the
relevant points for <b>"Diabetes and Cardiovascular (CV) Risk"</b> shall be discussed.</p>
<p class="art-para">First, "<i>CV Risk Factors</i>" have to be considered. A very high risk factor is, besides
documented CV disease and severe chronic kidney disease (CKD), diabetes mellitus with
target organ damage. The other diabetic patients are at high risk, in addition to subjects
having cholesterol levels >8 mmol/L / >310 ng/dl or a blood pressure >/=180/110 mm
Hg, . Young type-1-diabetes patients without major risk factors, however, may be at low
or moderate risk.</p>
<p class="art-para">Second, a CV Risk Score for the 10-year risk of fatal CV disease (CVD) has to be
calculated specifically for different countries. The CV risk score depends from gender,
smoking, age, total cholesterol and systolic blood pressure as well as from the country
epidemiologic data concerning CV mortality. E.g. Algeria, Belarus, Egypt, Russia and
Ukraine belong to a group of countries with a very high risk, in contrast to low risk
countries located in western, northern or central parts of Europe.</p>
<p class="art-para">Risk Factor screening has to be considered in men >40ys and women >50ys or
postmenopausal. The Risk Score can assist in decisions, avoiding both under- and
overtreatment. People at high or very high CV risk do not need risk scoring: They require
immediate attention to all risk factors. This category includes patients with documented
CVD, diabetes or chronic kidney disease.</p>
<p class="art-subhead" id="diagnosis">Diagnosis</p>
<p class="art-para">LDL-Cholesterol is the primary lipid parameter that should be assessed, Total
Cholesterol is usually not sufficient for the characterization of untreated dyslipidemia.
HDL-Cholesterol may also be estimated before treatment. Triglycerides add information
about the risk level, and their measurement is indicated for diagnosis and choice of
treatment. Lipoprotein(a) may be determined in selected cases at high risk.</p>

<p class="art-subhead" id="pharmacologic">Pharmacologic treatment of hypercholesterolaemia</p>
<p class="art-para">Prescribe a statin up to the highest recommended or tolerable dose to reach the
goal.</p>
<p class="art-para">Statin intolerance: etzetimibe or a bile acid sequestrant, or both
Goal not reached: statin combination with a cholesterol absorption inhibitor or a
bile acid sequestrant. In selected cases: a PCSK9 inhibitor</p>
<p class="art-subhead" id="goals">Treatment goals</p>
<p class="art-para">In T1D with renal involvement: LDL-lowering (at least
50%) with statins irrespective of the baseline LDL-concentration</p>
<p class="art-para">In T2D with CVD or CKD or >40ys: LDL <1.8 mmol/L / <70
mg/dL</p>
<p class="art-para">In all patients with T2D without additional risk factor LDL
< 2.6 mmol/l / <100 mg/dL.</p>
<p class="art-para">This is in contrast to the US. In Europe it is recommended
to "Treat to Target" and not "Fire and Forget".</p>
<p class="art-para"><b>"RULE of 6":</b> Each doubling of the statin dose leads to a 6%
LDL-cholesterol-lowering only</p>
<p class="art-para">Do not drink grapefruit juice. It interacts with statins
metabolized by CYP3A4 leading to increased risk of myopathy
and rhabdomyolysis. </p>

<p class="art-subhead" id="style">And do not forget life style!</p>
<p class="art-para"><b>Conflicts of Interest:</b>
The author reports no conflict of
interest.</p>
<p class="art-subhead" id="literature">Literature</p>
<p class="art-para">Committee for Practice Guidelines to improve the quality
of clinical practice and patient care in Europe: Dyslipidaemias.
Rome, August 2016. www.escardio.org/guidelines</p>

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