KLE College of Pharmacy, India
Despite the stringent Regulatory norms and WHO guidelines the fraud pertaining to food additives particularly with reference to synthetic food coloring agents in spices and related products with recurrence of unauthorized adulteration of azo food colors with perspective of improving food texture and providing bright glossy appearance has been a rising concern over past few decades. The quality qualitative/quantitative methods along with analytical tools like TLC and HPLC seem to have fallen short in terms of identification and detection at trace levels of restricted compounds in food. Moreover the safety concern of azo food colors is still debated due to their nature origin and most importantly the doubt is still to be cleared between the use of synthetic azo food dyes and their so far observed detrimental effects like hypersensitivity, allergic reactions and skin sensitizations behavioral abnormalities in infants and other groups consuming confectionaries dairy products, spices and related products. The present study deals with identification and detection of restricted aromatic azo amines with carcinogenic potential in food and related products by use of chromatographic and spectroscopic technique like TLC-MS, LC-MS in combination. The hyphenation of both the technique is done with an effort to bridge most debated gap between the use of synthetic azo colorants and their determined effects. The study thus confirms the need to extent analytical scope of any monitory method to get most reliable and reproductive results.
Biography:
Shrikrishna M. Nandanwadkar currently, pursuing his doctoral study in Pharmaceutical Quality Assurance at KLE Academy of Higher Education and Research, Belagavi, India. He is an active member of the Society of Ethnopharmacology (SFE) and Society of Pharmacognosy and had been in the field of Chromatography for the past 5 years and has hands-on experience on related sophisticated instruments.
He had presented his research work at various National and International conferences like Advances in Drug Discovery and Development at Manipal University, CSIR-NBRI and MFU University, Thailand had presented his research work in form of scientific paper presentation.
KLE College of Pharmacy, India
The nanosuspension containing riluzole is an active constituent to treat amyotrophic lateral sclerosis and related conditions. The riluzole nanosuspension was formulated by solvent anti-solvent precipitation technique using various polymer/stabilizer combinations such as HPMC-K15 and Tween 80. Further six different formulation were prepared amongst which 4th was optimized in respect to particle size, zeta potential, polydispersity index, entrapment efficiency, drug content and transmission electron microscopy.
In this proposed research work, an effort was made to develop the analytical method for riluzole which is an antiepileptic drug by using High Performance-Thin Layer Chromatography (HP-TLC) technique under optimized chromatographic conditions using semi-polar solvent system with retention factor value 0.84±0.10 of nanosuspension containing riluzole pure active pharmaceutical ingredient and further the spectral analysis exhibited λmax at 263.5 nm.
Biography:
Chaitrali Bidikar had completed her Bachelor and Master Program in KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, India from Department of Pharmaceutical Quality Assurance. She had been trained on various equipments like HP-TLC, HPLC and Nanotrac. She has been awarded with Ratan Tata scholarship and a member of Society of Ethnopharmacology. She has presented scientific paper at Manipal University at International congress of SFE and also participated in Inter-college competitions and have taken active participation in cultural activities of college.
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