School of Pharmacy, Keele University, UK
Background: Trastuzumab is indicated for the treatment of early stage breast cancer which over expresses human epidermal growth factor receptor 2 (HER-2), metastatic breast cancer and metastatic gastric cancer with HER-2 positive tumours. A subcutaneous (SC) formulation for trastuzumab has been marketed in UK since September 2013. Studies showed that SC trastuzumab are more cost effective and more preferred by healthcare professionals and patients than intravenous (IV) trastuzumab. Biosimilar trastuzumab launch is anticipated in the UK market in 2018 in IV dosage form.
Purpose: To investigate the impact of the introduction of SC trastuzumab on the utilisation of intravenous trastuzumab and size of accessible market for biosimilar trastuzumab in the UK.
Methods: An autoregressive integrated moving average model was conducted on the secondary care utilisation data of trastuzumab (in grams) from the DEFINE database, between 2012-2017.
Results: The overall utilisation of trastuzumab doubled following the launch of SC trastuzumab from 2831g in January 2012 to 5697g in December 2017. The utilisation of IV trastuzumab decreased significantly following the introduction of SC trastuzumab. The utilisation trend of the IV formulation before and after the introduction of SC trastuzumab were 28.3 and -57.8 g/month (p>0.004) respectively. The utilisation trend of SC trastuzumab increased significantly by 58.1 g/month (p>0.001) and achieved 74% of the trastuzumab market by December 2017.
Conclusion: SC trastuzumab changed dramatically the market profile of trastuzumab and reduces the accessible IV market share for competition with upcoming biosimilar trastuzumab. Previous research has shown that biosimilars launched in recent years have entered the market at 30% less than the originator brand and prices have stabilised at approximately 50%, but these have all been with similar formulations. It is not yet clear whether such price decreases will be enough to change the current market profile of trastuzumab in the UK.
Biography:
Dr. Mohammed Aladul qualified as a pharmacist in 2007 after graduating from University of Mosul, Iraq and preregistration training at Avicenna General Hospital in Mosul. He worked as a hospital pharmacist and studied for an MSc in Clinical Pharmacy, graduatingin 2013. Subsequently he moved to the University of Mosul as Director of Pharmacy. He started my PhD at the School of Pharmacy Keele University, in 2015, undertaking both quantitative and qualitative analysis of biosimilar, have published 5 research articles to date based on this work.
1Department of Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Israel
2Department of Nursing, Ben-Gurion University of the Negev, Israel
Introduction: A large body of evidence suggests that inflammation is involved in the pathophysiology of several neurological disorders, including psychiatric illnesses, neurodegenerative diseases and stroke. Nuclear Factor-k B (NF-kB) is a cellular pathway that plays a prominent role in numerous immune and inflammatory responses in mammals.
Aims: This study was undertaken to examine the effects of a selective NF-kB inhibitor, JSH-23, on lipopolysaccharide (LPS)-induced inflammation in rats.
Materials and Methods: Rats were treated with JSH-23 (10 mg/kg) through a single intraperitoneal (ip) injection. JSH-23 was administered at (i) 2.5 h before or at (ii) 1.5 h after LPS (1 mg/kg, ip) injection. At 4 h (i) and 2.5 h (ii) after JSH-23 administration, rats were sacrificed, blood was collected and different brain regions were excised. Levels of the inflammatory constituents interleukin (IL)-6, prostaglandin (PG) E2, tumor necrosis factor (TNF)-a and nuclear phosphorylated p65 (P-p65) in plasma and brain were examined by specific ELISA kits.
Results: The effects of JSH-23 on plasma and brain inflammatory mediatorsʼ levels differed between the pre- and - post-LPS administration schedule and between the various brain regions. Mostly, JSH-23 treatment reversed the changes in IL-6, PGE2, TNF-a and P-p65 levels in plasma, frontal cortex, hippocampus and hypothalamus of LPS-treated rats.
Conclusions: These results suggest that inhibition of NF-kB may have a therapeutic potential for the treatment of inflammation-associated brain disorders.
Biography:
Dr. Jacob Kaplanski completed his Ph.D. in pharmacology in the Department of Pharmacology in the Hebrew University in Jerusalem (Israel). There after, he completed his post-doctoral fellowship in the Department of Pharmacology in the Free University of Amsterdam (The Netherland). He mentored numerous M.Sc. and Ph.D. students in the fields of Pharmacology and exercise physiology. He has authored more than 100 peer-reviewed research papers.
1Department of Medicine, University of Latvia, Latvia
2Department of Geography and Earth Sciences, University of Latvia, Latvia
Adipose tissue derived mesenchymal stem cells (aMSCs) are an attractive source for regenerative therapy due to their unique ability to form osteocytes, chondrocytes and adipocytes in vitro after appropriate stimuli. Therefore, aMSCs may serve as a valuable tool for screening of pharmacologically active compound effect on tissue engineering. Plant pigments anthocyanidins are known for their anti-oxidative, anti-inflammatory and anti-tumor propertiesas well as for influence on wound healing. Anthocyanidin effect onaMSC differentiation may lead to design of new therapeutic strategies for regenerative medicine.
The objective of the current study was to evaluate the effect of anthocyanidinsmalvidin, cyanidin, delphinidin on the adipogenic, osteogenic and chondrogenic differentiation of human aMSCs.
aMSCs (ATCC, PCS-500-011) were differentiated into adipocytes, osteocytes and chondrocytes by Gibco®StemPro® differentiation kits according to manufacturerʼs instructions. 25µM malvidin, cyanidin and delphinidin (all from Sigma Aldrich) were added to aMSCs during the differentiation. The expression of adipogenesis, osteogenenesis and chondrogenesis related markers was analyzed by qPCR and ELISA. 10 and 100nM liraglutide (TRC Research) was used to compare anthocyanidin effects on aMSCs differentiation.
Delphinidin decreased the expression of FABP4 and Adiponectin similarly to liraglutidein newly formed adipocytes. Malvidinand liraglutideincreased the accumulation of calcium deposits and expression of Runx2 and BMP-2in the osteocytes. Delphinidin, cyanidinand liraglutidesignificantly induced the expression of Col2a1 and Aggrecan in the chondrocytes.
Delphinidin and anti-obesity drug liraglutide inhibit formation of adipocytes from aMSCs. Malvidin and liraglutideinduce the osteogenesis, whereas cyanidin, delphinidinand liraglutidepromote osteogenic and chondrogenic differentiation.
Biography:
Liga Saulite is a PhD student at Pharmacy study program of Faculty of Medicine of University of Latvia. She has received BSc and MSc degrees in Biology at University of Latvia. She has studied Biochemistry and Molecular Biology at University of Bremen and Molecular Cancer biology and laboratory animal welfare in University of Oslo. Her main expertise includes mesenchymal stem cells, breast cancer cells, nanoparticles, neurodifferentiation and Schwann cells. She is co-author in four scientific publications.
1Korea Institute of Science and Technology, Republic of Korea
2Konkuk University, Republic of Korea
Metabolite identification of AZD8055, which is an ATP-competitive specific dual mTOR inhibitorand exhibited potent antitumor activity on several types of solid tumors, was performed using ultra high-performance liquid chromatography-ion trap mass spectrometry (UHPLC-IT-MS) through both in vitro and in vivo approaches using rat liver microsomes (RLMs) and rat plasma, urine and feces, respectively. A total of eight putative metabolites (five phase I and three phase II) were identified, and a tentative metabolic pathway was suggested for the first time. Considering the accurate mass and mass fragmentations of the detected metabolites, their plausible structures were suggested. Demethylation, hydroxylation, oxidation and morpholine ring opening were the major biotransformation processes for the phase-I metabolism, while phase-II metabolites were merely generated by the glucuronide conjugation reaction. The cumulative excretion of AZD8055 in urine and feces was 0.13% and 1.11% of the dose, respectively. When the semi-quantitative analysis of the metabolites was performed using UHPLC-MS/MS (ultra-performance liquid chromatography tandem mass spectrometry) to evaluate the overall trend of metabolites formation and excretion, AZD8055 was excreted more in the form of the metabolites than itself and their formation was very fast. Therefore it was presumed that biotransformation was playing a crucial role in its elimination. Ultimately, this study provides novel insights regarding the in vitro and in vivo bio transformations of AZD8055. Further investigations of metabolites of this potent anti-cancer compound could be beneficial for the antitumor drug design and development process
Biography:
Byung Hwa Jung has her expertise in metabolomics and DMPK (drug metabolism and pharmacokinetics). She has developed analytical methods for the quantitative and qualitative determination of endogenous metabolites and xenobiotics (drugs). The platforms for the non-targeted metabolomics and lipidomics using LC-MS for the evaluation of metabolic change in in vivo and in vitro systems were already established in her lab. Along with these systems, the quantitative analytical platforms for more than 170 metabolites and several drugs were also set up. The mechanisms and biomarkers for disease generation and development, and drug effect and adverse effects are studied with those systems.
Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, Poland
Mangiferin (2-C-b-glucopyranosyl-1, 3, 6, 7-tetrahydroxyxanthone) is the polyphenol with strong antioxidant properties. Mangiferin is obtained from mango tree (Mangiferaindica, L. Anacardiaceae). Significant amount of mangiferin is observed in honeybush (Cyclopiasp., Fabaceace)and Anemarrhenaasphodeloides(Liliaceae). It was proved that mangiferin exhibit many pharmacological activities. In our previous study we identified that mangiferin enhances apoptotic effects of hesperidin in human cervix adenocarcinoma cell line (HeLa) [1] and thatmangiferinhas the ability to penetratethrough the stratumcorneumbarrier and to the living skin layers, wherecollagenase and elastaseoccur [2]. We indicatedthat, mangiferininhibitselastase and collagenaseactivity in a reversiblemanner, referred to as a non-competitiveinhibition [2].
In the presentstudy, inhibitory effect of mangiferin on mushroom tyrosinase activity were examined. Tyrosinaseis a copper containing enzyme which is responsible for the first two steps of melanogenesis, process of melanin synthesis. Tyrosinasecatalyses melanin biosynthesis in human skin and epidermalhyperpigmentationmaycausevariousdermatologicaldisorders.
The research proved that mangiferin inhibits tyrosinase activity in a dose dependent manner. Mechanism of inhibition was described as mixed inhibition with predominance of non-competitive inhibition.
Biography:
Renata Ochocka is Professor of Pharmacy. She is the head of the Department of Biology and Pharmaceutical Botany at Faculty of Pharmacy, Medical University of Gdańsk, Poland. Her professional interests focus determination of bioactive compounds from medicinal plants and the investigation their biological activity.
1Natural Products Research Center, Korea Institute of Science and Technology, Republic of Korea
2Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Republic of Korea
3Department of Food and Nutrition, Gangneung-Wonju National University, Republic of Korea
4Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Republic of Korea
Ginger, one of worldwide consumed dietary spice, however, it is not only famous as food supplements, and also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has anti-inflammatory effect with comparable activity to positive control 6-shogaol in lipopolysaccharide (LPS)-activated microglial cells, including interleukin (IL)-6, tumor necrosis factor (TNF)-α, prostaglandin (PG) E2, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated Akt/IKK/NF-κB pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on pro-inflammatory mediators such as NO and TNF-α by using HO-1 inhibitor. These results indicate that 12-DHGD protects against neuro-inflammation by inhibiting Akt/IKK/IκB/NF-κB pathway and promoting Nrf-2/HO-1 pathway.
Keywords: Ginger; 12-Dehydrogingerdione; Neuro-inflammation; Microglial cells
Biography:
Dr. Hyun Ok Yang has complete her PhD on pharmacognogy at Seoul National University in 1993. After Post-doctoral study at University of Iowa, USA, she is now a principal research scientist at Natural Products Research Center in Korea Institute of Science and Technology (KIST) & a professor of UST, KIST School, and Republic of Korea.
1Ankara Yildirim Beyazit University, Turkey
2Saglik Bilimleri University, Turkey
3Guven Hospital, Turkey
Propofol is an intravenous anesthetic that can be used for the induction and maintaining of anesthesia. The purpose of this study is to investigate the mechanism of the vasodilator action of propofol in the human internal mammary artery (IMA).
The IMA rings were hung in isolated organ baths and the changes in tension were recorded isometrically. Potassium chloride (KCl) and phenylephrine (PE) were added to organ baths to form precontraction. Propofol (1, 10, 100 µM) was added cumulatively when the precontractions were stable. The antagonistic effect of propofol on KCl (mM), PE (1 µM), 5-hydroxytryptamine (5-HT, 30 µM) and calcium chloride (CaCl2, 10 µM-10 mM)-induced contractions in the vascular rings were investigated. Propofol-induced relaxations were also tested in the presence of the large conductance calcium-activated potassium channel inhibitor tetraethylammonium (TEA, 1 mM), the adenosine triphosphate-sensitive potassium channel inhibitor glibenclamide (GLY, 10 µM), the voltage-sensitive potassium channel inhibitor 4-aminopyridine (4-AP, 1 mM) and the inward rectifier potassium channel inhibitor barium chloride (BaCl2, 30 µM).
Preincubation with propofol (1, 10, 100 µM) did not affect the basal tone but inhibited the KCl, PE, 5-HT and CaCl2-induced contractions. Propofol-induced relaxation was not affected by 4-AP, GLI, BaCl2. But, TEA inhibited propofol-induced relaxations significantly.
Present experiments show that propofol relaxes contracted IMA and inhibits the KCl, FE, 5-HT and CaCl2-induced contractions. The results demonstrate that the mechanism of action of propofol-induced vasodilation in the IMA may be related to BKCa activation.
Keywords: Propofol, Internal Mammary Artery, Potassium Channels, Vasodilation
Biography:
Dr. Arslan is the head of pharmacology department in the Ankara Yildirim Beyazit University. His research interests focus on the experimental pathophysiology and inflammation of pulmonary and cardiovascular systems. He is the PhD supervisor for pharmacology and toxicology students.
1Ankara Yildirim Beyazit University, Turkey
2Saglik Bilimleri University, Turkey
3Adiyaman University, Turkey
Propofol is an intravenous anesthetic that can be used for the induction and maintaining of anesthesia. In this study, it was aimed to investigate the mechanism of vasodilator action of propofol in rat aorta (RA).
The RA rings were suspended in isolated organ bath and tension was recorded isometrically. First, potassium chloride (KCl) and phenylephrine (PE) were added to organ baths to form precontraction. When the precontractions were stable, propofol (1, 10, 100 µM) was added cumulatively to the baths. The antagonistic effect of propofol on KCl (mM), PE (1 µM), 5-hydroxytryptamine (5-HT, 30 µM) and calcium chloride (CaCl2, 10 µM-10 mM)-induced contractions in the vascular rings were investigated. Propofol-induced relaxations were also tested in the presence of the large conductance calcium-activated potassium channel inhibitor tetraethylammonium (TEA, 1 mM), the adenosine triphosphate-sensitive potassium channel inhibitor glibenclamide (GLY, 10 µM), the voltage-sensitive potassium channel inhibitor 4-aminopyridine (4-AP, 1 mM) and the inward rectifier potassium channel inhibitor barium chloride (BaCl2, 30 µM).
Preincubation with propofol (1, 10, 100 µM) did not affect the basal tone but inhibited the KCl, PE, 5-HT and CaCl2-induced contractions. Propofol-induced relaxation was not affected by 4-AP, GLI, BaCl2. But, TEA inhibited propofol-induced relaxations significantly. Comparison among multiple groups was made by using a one-way ANOVA followed by Scheffeʼs post hoc test to determine significant differences among the means of the data groups.
The propofol induces relaxation in contracted RA and inhibits KCl, FE, 5-HT and CaCl2-induced contractions. The results demonstrate that the mechanism of action of propofol-induced vasodilation in the RA may be related to BKCa activation.
Keywords: Propofol, Rat Aorta, Potassium Channels, Vasodilation
Biography:
Dr. Arslan is the head of pharmacology department in the Ankara Yildirim Beyazit University. His research interests focus on the experimental pathophysiology and inflammation of pulmonary and cardiovascular systems. He is the PhD supervisor for pharmacology and toxicology students.
1Department of Medical and Pharmaceutical Sciences, University of Sucre, Colombia
2Department of Biomedical Research Group, University of Sucre, Colombia
3Foundation University Technological of Comfenalco, Colombia
4Laboratory of Inorganic Chemistry and Catalysis, University of Quindio, Colombia
Current treatments for Alzheimerʼs disease are focused on symptomatic therapy, since not targets have been identified. The aim of this study was to discover small molecules acting on β-Secretase, γ-Secretase, Pin1 and Cdk5 proteins, and its pharmacological evaluation. The proteins 3D structures were downloaded from the PDB database and were docked, using AutoDockVina, with molecules having drug-like properties. Initial analysis results reveal four potential compounds capable of binding to evaluated proteins which have affinity values ranging between -6.8 and-9.1 Kcal/mol. The interaction of ligands 84554447, 84577234, 84577855 and 84378305 with 4U84 protein (PDB ID), allowed the identification of residues SER32, ALA31 and LYS97 as the main amino acids involved in the protein-ligand docking. In the case of the4UPC protein, the residues identified were CYS230, VAL51, ALA172, PHE287, ARG285, TYR173 and THR227. With 3VF3 protein, the amino acids were GLN73, THR218 and GLY217 and with 3O0G, the residues were ALA31, ASN144 and VAL64. Of the compounds having the highest affinity value, one was selected to perform the pharmacological evaluation. Thus, the compound 84378305 (Pubchem ID) was synthesized by chemical synthesis, to subsequently evaluate its neuroprotective effect, by the MTT and DHL release assays. The pharmacological evaluation showed that the synthesized compound has low cytotoxicity and is an effective neuroprotect. In conclusion, it was possible to find by in silico and experimental evaluation a ligand capable of acting against proteins related to Alzheimerʼs disease and which possess neuroprotective activity.
Biography:
Nerlis Pajaro holds a masters degree in pharmaceutical sciences and PhD candidate in environmental toxicology. At present she is an associate professor at the faculty of health sciences of the University of Sucre. Her research is focused on the area of pharmacology, toxicology, in silico drug design and chemistry medicine. Since several years she has been working on several research projects related to discovering molecules for the treatment of Alzheimer through in silico search and pharmacological evaluation, and evaluation of the toxicity of organic compounds using the insect Triboliumcastaneum as in vivo model.
Jordan University of Science and Technology, Jordan
Among healthcare professionals, substance-use behaviors and disorders greatly affect the provision of healthcare services (e.g. pharmaceutical services). Pharmacists play a central role in medical care and are medication experts, however, they are considered as highly vulnerable to substance-use disorders. Thus, pharmacy practice and patientsʼ health might be threatened. As compared to general college students, research suggests that healthcare professional students are at higher risk for problematic substance-use behaviors. However, less research has examined substance-use among student pharmacists in comparison to other healthcare professional students. This study represents a literature review that describes and summarizes student pharmacistsʼ substance-use behavior in the United States. The purposes of literature review were: to highlight what is known about substance-use behaviors among student pharmacists, and to identify factors that might influence problematic substance-use behaviors among them. This review includes studies completed within US colleges and universities identified through multiple databases. Articles on student pharmacistsʼ substance-use behaviors focusing on substance-use rates or levels, motives for any substance-use, and substance-use related problems were included. The literature search identified 16 studies. Current literature indicates that there are problems with alcohol and other drug use among student pharmacists. Although researchers have found variations in the type and rate of reported substance-use, significant proportions of student pharmacists were identified as being at high risk for substance-use disorders. Findings suggest that pharmacy schools should encourage and stimulate more research in order to implement effective screening and early intervention programs in an effort to address this important student health issue.
Biography:
Dr. Samah AL-Shatnawi Ph.D, is an assistant professor at the Clinical Pharmacy department, Jordan University of Science and Technology. Her research interests span over several areas related administrative pharmacy fields, including pharmaceutical behaviors, behavioral substance use, substance use disorders, and health outcomes. Within Pharmacy Practice, substance-use behaviors and disorders among healthcare professionals (pharmacists and student pharmacists) is one of her favorite research topics.
Samah AL-Shatnawi earned Pharm.D degree from Jordan University of Science and Technology (JUST), Jordan in 2009. Immediately after graduation, she worked as a researcher and teaching assistant at JUST and she was awarded JUST Clinical Pharmacy Research Scholarship (2012-2015) for pursuing her Ph.D. degree. For Ph.D. dissertation, she applied theoretical models and utilized quantitative research methods to study Alcohol Use Behaviors and Outcomes in Professional Student Pharmacists. During her graduation study period, she co-authored articles and several presentations as a primary and secondary author. Currently she is supervising many master-degree students to conduct prospective (primary data) and retrospective (secondary data) research within the field of pharmacy practice.
1University of Mouhamed kheidar Biskra, Algeria
2Laboratory of applied Biochemistry and microbiology, Badji Mokhtar University, Algeria
This study has allowed to confirm the physicochemical characteristics and fatty acid composition by GC of the oil of Pistacia lentiscus extracted by traditional method and evaluate its effect on some blood lipid parameters. The results showed that the main physicochemical characteristics of Pistacia lentiscus oil are: moisture (0.84%), a relatively high iodine value (80, 44) indicating that this oil has an important degree of unsaturation. The oil is mainly composed of unsaturated fatty acids (MUFA) where oleic acid dominate with 47, 01% of total fatty acids and PUFAs represented by linoleic acid (19, 26%). Concerning the biological survey, oil, at 10% and 20% doses of diet for 15 and 30 days of two periods of treatment, resulted in beneficial effects on the lipid profile of Wistar albinos rats previously fed with animal and vegetable fats. We observed decreases in total cholesterol, triglycerides (TGA), total lipids and LDL-C, and an increase in HDL-C “good cholesterol” probably related to the presence of a large amount of (MUFA) and (PUFA).
Keywords: Pistacia Lentiscus, oil, lipid profile, monounsaturated fatty acids, Poly unsaturated fatty acid
Biography:
Dr. Merzougui Imene, master conference categorie B, PhD in applied biochemistry, is from department of Biology (option :Biochemistry) Mohammed kheidar University (Biskra-Algeria). She made her superieur study in badji mokhtar university (Annaba-Algeria).
Her main research interests include Phytotherapy, with medicinal plants for the therapy of chronic diseases like Diabetes especially type II and he has research which based on virgin vegetable oils which contain (mono and polyunsaturated fatty acids) for the regulation of lipid profile especially cholesterol and LDL-Cholesterol to the normal average, she supervises students in biochemistry as part of a masterʼs thesis since 2016.
She has published papers in international journals, such as ‘EUROPEAN Journal of scientific researchʼ.
Jordan University of Science and Technology, Jordan
Bacteria have the ability to form complex surface-associated communities known as biofilms. These biofilms are commonly associated with many health problems, as many persistent and chronic bacterial infections are thought to be linked to biofilm formation. Compared to planktonic cells, biofilms are characterized by significant antibiotic resistance as well as high virulence potential, which explain why biofilms are associated with tremendous impact on health including increased morbidity and mortality. Moreover, complications related to biofilms often result in additional hospitalization and medical care for patients, leading to substantial economic impact. In this study we are proposing to investigate in vitro susceptibility of methicillin resistant Staphylococcusaureus (MRSA) strain ATCC 43300 to selected antibiotics from the fluoroquinolone class. Antibiotics efficacy against MRSA biofilm bacteria is compared to planktonic state. The susceptibility of the six fluoroquinolones demonstrated variable activity against MRSA bacteria as they were not equipotent. For planktonic cells, the MIC values showed that moxifloxacin (0.049µg/ml), Gatifloxacin (0.078µg/ml) and levofloxacin (0.156µg/ml) were the most effective, while norfloxacin (1.172µg/ml) was the least effective. This was confirmed by measuring the diameter of the zone of inhibition. The results showed the same order of activity as the MIC values against planktonic cells. The biofilm cells, on the other hand, demonstrated less sensitivity against toward the same antibiotics used against planktonic counterparts. In this case, Gatifloxacin (328.13µg/ml) was the most effective, followed by moxifloxacin (390.63µg/ml) and ciprofloxacin (437.5µg/ml). However, similar to the planktonic bacteria, norfloxacin (875µg/ml) was the least effective against biofilm cells as well. These data conclude that biofilm cells are less susceptible to antibiotics compared to the planktonic cells. It is also evident from these data that some antibiotics are more effective when used against biofilm cells, while others perform better on the planktonic counterparts. Results of this project are expected to provide insight into the efficacy of various fluoroquinolone antibiotics against MRSA biofilms. This study could form the basis for future clinical studies that could recommend special guidelines for management of infections that are likely to involve bacteria in their biofilm state.
Biography:
Dr. Majed Masadeh is an Associate Professor of Pharmaceutical Microbiology at the Pharmacy College of Jordan University of Science and Technology, where he teaches pharmaceutical microbiology and biotechnology, pharmacology and basic microbiology courses (since Sep 2005). Dr. Majed holds a Doctor of Philosophy (Ph.D) degree in Pharmacy (majoring in Pharmaceutical Microbiology) from The University of Abertay Dundee at United Kingdom (UK). In addition, Dr. Masadeh holds a Bachelor of Science degree in Microbiology (India), Master of Science in Medical Microbiology (India). Dr. Majed has expertise in bacterialbiofilm resistance investigation towards antimicrobial agents, research design, and scientific writing. Dr. Majed has published 38 papers in peer reviewed journals including the Current Microbiology, Drug Design, Development and Therapy, Annals of Clinical Microbiology and Antimicrobials, Infection and Drug Resistance, International Journal of Integrative Biology, Clinical Medicine Research, Pharmaceutical Biology, Cytotechnology, International Journal of Occupational Medicine and Environmental Health, Journal of Infection in Developing Countries, Electromagnetic Biology and Medicine, Prevalence of Depression among Relatives of Cancer Patient in Jordan. Palliative & Supportive Care, Journal of Pharmacy and Bioallied Sciences, Pakistan Journal of Pharmaceutical Sciences, etc... In Sep 2013, Dr. Majed wasselected inthe Academickeys Whoʼs Who in Pharmacy Higher Education (WWPHE) from September 2013. Dr. Majedreviewer for: International Journal of Nanomedicine: Dove Medical Press, International Journal of Medical Devices: Evidence and Research, British Journal of Pharmaceutical Research (BJPR), European Journal of Medicinal Plants, British Microbiology Research Journal, International Journal of Cell Culture and Biotechnology, (Cytotechnology), JJBS for Jordan Journal of Biological Sciences etc...
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