International Neurology Conference
December 3-4, 2018 Valencia, Spain
Association between Amisulpride Treatment and Dopamine D3 Receptor Gene Polymorphisms in Korean Schizophrenic Patients
Dongguk University, Republic of Korea
Objectives: The aim of this study is to evaluate the association between rs6280 and rs905568 genetic polymorphism of DRD3 gene and the treatment response of amisulpride.
Methods: After six weeks treatment of amisulpride, 125 schizophrenia patients were interviewed based on the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity (CGI-S). The genotyping for rs6280 and rs905568 was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay.
Results: There was no significant difference in the frequency of genotype and allele of rs6280 between the responders and nonresponders based on the total, positive, and general score of PANSS and CGI-S score. However, there was a significant association between this SNP and treatment response in the negative score of PANSS (χ2 = 5.23, p = 0.022). There was no significant association between rs905568 and the response in positive, negative, general, and total PANSS score and CGI-S score.
Conclusions: This is the first positive association study between DRD3 gene and the treatment response of negative symptoms to amisulpride in Korean schizophrenia patients. A larger scale research on more SNP of the DRD3 gene will make a progress in the study of pharmacogenetics on the treatment response of the amisulpride.
Keywords: Treatment response, Amisulpride, DRD3 gene, Polymorphisms rs6280.
Dr. Kwanghun Lee is Chair of Department of Psychiatry, Dongguk university hospital, Gyeongju, Republic of Korea President of Korean Society of Biological therapies in psychiatry, Board member of directors of KCNP.